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KMID : 0384119910110030643
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Korean Journal of Clinical Pathology
1991 Volume.11 No. 3 p.643 ~ p.654
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Liver Disease and Anti-HCV Antibody
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S. M. Choi
J. A. Kang/K. E. Song/J. S. Suh/W. K. Lee/J. S. Kim
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Abstract
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Present study was conducted to determine the frequency of antibodies to hepatitis C virus in patients with liver diseases. Study population consisted of 396 patients with various liver diseases and 108 patients with other diseases. The enzyme-linked immunosorbent assay was used to detect anti-HCV. Anti-HCV was detected in 9.1% (46 out of total 504 patients), 10.6%(42/396) of liver diseases and 3.7% (4/108) of other diseases. Anti-HCV was detected in 17.7% (11/62) of primary hepatoma, 14.3(12/84) of liver cirrhosis, 10.1%(12/119) of chronic hepatitis, 6.4%(3/47) of fatty liver, 6.1%(3/49) of other chronic liver diseases and 3.8 % (l/26) of acute hepatitis. Of anti-HBc positive patients, 12.8% (34/265) was positive for anti-HCV. Anti-HCV was positiven in 10.4%(31/298) of patients with increased ALT, and in 12.5%(24/192) of patients with both positive anti-HBc and increased ALT. Anti-HCV positive patients showed positive anti-HBc in 80.9 % (34/42), increased ALT in 73.8% (31/42), and either anti-HBc positive or incrgased ALT in 97.6%(41/42), In relation to HBV marker, the frequency of anti-HCV was increased more in patients with HBV antibody than with HBV antigen, especially in primary hepatoma. In summary, it can be concluded that HCV antibody determination is a very useful test for the determination of etiology in not only posttrasfusion hepatitis but also various chronic liver diseases such as primary hepatoma, chronic hepatitis and liver cirrhosis.
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